Tag Archives: sepsis

miniRAGE: The ProCESS Trial

Relax, we didn’t really delete the discussion of The ProCESS Trial from RAGE Session Four… We just chopped it out to be published separately as a miniRAGE.

This is what we’re talking about:

ProCESS Investigators, Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014 May 1;370(18):1683-93. doi: 10.1056/NEJMoa1401602. Epub 2014 Mar 18. PubMed PMID: 24635773. [Full Text] [Supplement]

So, following on from Haney’s comments on the Surviving Sepsis Campaign response to ProCESS, here is the RAGE team talking about what it all means for the management of septic shock.

Learn more here:

Thanks again for listening to the RAGE!

RAGE Session One

You’d be forgiven for thinking it was never going to happen… but it has… the first RAGE Session is finally here!

RAGE Session One is 71 min 7 sec long and includes:

  • Introduction, including the RAGE team ‘meet and greet’ (starts 00:00 min)
  • ‘What’s bubbling up?’ (starts 05:40 min) — shout outs and interesting discoveries from the world of FOAM and elsewhere featuring CO2 retention in COPD, the LINC trial, intraosseous blood transfusion, Rory Spiegel’s EM Nerd, the ‘quick look’ CT in ‘semi-stable’ trauma patients and fallen cycling legend Martyn Ashton
  • the RAGE team discussing ‘The post-TTM era: homeopathic hypothermia or aggressive normothermia?’ (starts 25:20 min)
  • the RAGE team’s discussion on ‘Septic and hypotensive: what next?’ (starts 39:06 min)
  • ‘A blast from the past’ on critical care deity Peter Safar, presented by Haney Mallemat (starts 63.57 min)
  • ‘Wise Words’ featuring Descartes and Diderot, presented by Michelle Johnston (starts 67.58 min)

It’s early days and we expect to incrementally improve the format, presentation and audio quality with each episode. To make this happen, we need your feedback — leave comments on this post or contact us here (especially if you want to appear on the show, correct us or respond to an episode in audio format).

The RAGE podcast has been submitted to iTunes , but is not yet available there  and is available here. The RAGE podcast audio feed is available here.

Read on for the ‘show note’ links for RAGE Session One…

Intro

What’s bubbling up?

httpv://www.youtube.com/watch?v=HhabgvIIXik

The post-TTM era: homeopathic hypothermia or aggressive normothermia?

  • Nielsen N et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med Nov 17 2013 doi: 10.1056/NEJMoa1310519
  • Reports of therapeutic hypothermia’s death are greatly exaggerated (LITFL)
  • All in a lather over TTM (LITFL)
  • Post-arrest care: EMCrit interview with Stephen Bernard part 1 and  part 2
  • Dumas F, et al. Is hypothermia after cardiac arrest effective in both shockable and nonshockable patients?: insights from a large registry. Circulation. 2011 Mar 1;123(8):877-86. doi: 10.1161/CIRCULATIONAHA.110.987347. Epub 2011 Feb 14. PubMed PMID: 21321156. [Free Full Text]
  • Kim F et al. Effect of Prehospital Induction of Mild Hypothermia on Survival and Neurological Status Among Adults With Cardiac ArrestA Randomized Clinical Trial. JAMA Nov 17 2013  doi:10.1001/jama.2013.282173
  • Jacobs IG, Finn JC, Jelinek GA, Oxer HF, Thompson PL. Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial. Resuscitation. 2011 Sep;82(9):1138-43. doi: 10.1016/j.resuscitation.2011.06.029. Epub 2011 Jul 2. PubMed PMID: 21745533.
  • Nehme Z, Andrew E, Bernard SA, Smith K. Treatment of monitored out-of-hospital ventricular fibrillation and pulseless ventricular tachycardia utilising the precordial thump. Resuscitation. 2013 Dec;84(12):1691-6. doi: 10.1016/j.resuscitation.2013.08.011. Epub 2013 Aug 27. PubMed PMID: 23994203.

Septic and hypotensive: now what?

Blast from the Past

Thanks for listening to the RAGE!

Special thanks to Scott Weingart and Rob Orman for technical advice in making this happen — we will follow your advice more closely next time ;-)